Chemical Rescue of Disease Mutations
Targeted covalent rescue
Using covalent small molecules to pharmacologically restore deregulated biological processes, such as transcription, catalysis, proteosomal degradation, in cancer mutations.
Expanded targetable proteome
Searching for functional groups that allow chemoselective, covalent engagement of amino acid residues currently deemed untargetable.
In vivo click chemistry
Using click chemistry methodologies to build bottom-up complexity to expedite therapeutics discovery for in vivo applications.
Latest Paper
Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras(G12D)
Leveraging the strain-release mechanism of malolactone-carboxylic acid ligation, we developed in vivo-active, mutant-selective inhibitors targeting K-Ras(G12D), the most common missense mutation in pancreatic ductal adenocarcinoma.
Lab News
- Welcome Jiyun!
We are excited to have our first postdoc fellow, Dr Jiyun Zhu, to join us from Stanford. Welcome, Jiyun! Jiyun received her B.Sc. in Chemical Biology from Sun Yat-sen University… - Welcome Tianfang!
We welcome our first rotation student, Tianfang Shen, from the Harvard Chemical Biology Graduate Program to join us. Tianfang graduated from Peking University with a BS in chemical biology. He… - Zheng Lab opened its door
Our Lab officially opened its door on June 2nd, 2025 in the Seeley G. Mudd Building. We are excited to launch our research program in the Department of Biological Chemistry… - Damon Runyon-Dale F. Frey Award
Qinheng was named a recipient of the 2025 Damon Runyon-Dale F. Frey Award for Breakthrough Scientists. The award supports paradigm-shifting research that will transform the way we prevent, diagnose and…