Research and Applications
Starting from a homogeneous blend of non-biochemistry related substances, we use light to start a Polymerization Induced Self-Assembly (PISA) reaction that triggers the boot-up of micron scale chemical systems. After forming, these grow, move, implode, self-reproduce and, for different types, compete for resources and show their “struggle for existence”.
Coupled nonlinear processes in simple models for artificial cells
We are interested in understanding what kind of meta-dynamics are capable of describing the basic set of properties that characterize living systems. The objective is to integrate these findings into a descriptive model capable of reproducing these gross features both at the qualitative and quantitative levels. Our work makes use of non-equilibrium field theory and collective phenomena, and is closely connected with observations and experiments carried out by others in the group.
Chemo-Mechanical Coupling in a BZ Gel
We are looking at problems associated to chemomechanical-coupling effects in gels and exploring how this class of phenomena relate to the basic properties of a living system. We are doing phenomenological as well as experimental work trying to understand how the chemistry and many body theory affect each other.
Giant Vesicles as a "Bootable All-Purpose Chassis"
We are studying the design and construction of polymer based giant vesicles. We plan to use them as selectively permeable containers for the chemical subsystems which, collectively, give rise to the emergence and sustainable evolution of artificial protocells.
Additional Topics
In addition to the above, we are investigating the transfer and management of information on living and chemical systems, as well as the nature of self-organizied processes giving rise to the above and, finally, the decoupling of degrees of freedom in non-equilibrium diffusion/reaction systems.
News and Commentary:
- "Dissipative Self-Assembly of Dynamic Multicompartmentalized Microsystems with Light-Responsive Behaviors" highlighted in preview article "Energy Dissipation at Interfaces Drives Multicompartment Remodeling", Chem 6(5), 2020
- "Scientists Create Self-Replicating Chemicals to Help Explain the Origins of Life", Vice
- "This Computer Is Made Entirely Out of Chemicals", Vice
- "How Chemistry Computes" highlighted in preview article "A Language for Molecular Computation", Chem 5(12), 2019
- "How Chemistry Computes" highlighted by iScience editors
- "Polymerization-Induced Self-Assembly", Advanced Science News
- "Mimicking Living Systems using Polymer Chemistry", Advanced Science News
- "Tracing the amphiphilic worm", Chemistry World
- "Mimicking life in a chemical soup", Harvard Gazette