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Medicine

Mining DNA for Disease Prediction: The polygenic risk score

by Alex Yenkinfigures by Allie Elchert Long before the completion of the Human Genome Project, scientists knew that many common diseases had a genetic component. However, there was debate about the architecture of these genetic effects: were there a…

James E. Bowman: Making history in science and society

by Tian Lu James Edward Bowman was born in Washington, D.C. on February 5, 1923. He grew up in a segregated environment which he described saying “there was complete segregation. … One could only go to theaters, movies, restaurants in the black…

Rebecca Lee Crumpler: Physician, Author, Pioneer

Jaclyn Long is a first year Ph.D. student in the Immunology Program at Harvard Medical School. Abby Knecht is a second year graduate student in the Molecules Cells and Organisms program at Harvard University where she is studying self versus non-self…

Rebecca Lee Crumpler: Physician, Author, Pioneer

Rebecca Lee Crumpler was born in Delaware in 1831. She was raised by her aunt in Pennsylvania, who often spent time caring for sick neighbors. Inspired by her aunt, Crumpler began working as a nurse in Charlestown, Massachusetts in 1852. During her eight…

Antibiotic uses multiple mechanisms to avoid resistance

Researchers developed a molecule that targets bacterial cells by two different mechanisms--attacking the cell membrane and disabling folate synthesis. This molecule seems to prevent bacteria from developing antibiotic-resistance.

Redesigning the polio vaccine - Lessons from evolution

Current polio vaccines have been successful in nearly eradicating polio in the world. Unfortunately, there have been emerging cases of polio in recent years. To combat this, scientists have designed a new oral poliovirus vaccine that could result in a…

Is diabetes communicable?

CIFAR Fellows’s paper questions whether diabetes, heart attacks and strokes are actually non-communicable diseases (NCDs). Microbiota (bacteria, viruses, fungi) that spread flu, HIV/AIDS, may also carry NCDs. People with NCDs have damaged microbiota,…