Welcome to the Shair Lab!
The Shair lab uses small molecules and cell biology as part of an integrated approach to study the mechanistic basis of human diseases, identify new druggable targets and develop therapeutics.
Research
The Shair lab uses small molecules and chemical biology as part of an integrated approach to study the mechanistic basis of human diseases, identify new druggable targets, and develop therapeutics.
Team
Our research is highly interdisciplinary, with chemists and biologists working side-by-side. Chemists apply modern stereoselective synthesis to discover highly selective small molecules that target proteins involved in human disease. Biologists combine small molecules with genome-wide and proteome-wide studies, CRISPR-Cas9 genome editing and iPSCs and primary patient samples to investigate human disease.
Publications
We invite you to explore our publications, including our recent study on uncompetitive inhibitors of N-methyl Nicotinamide Transferase (NNMT). Our work has optimized both the potency and the ADME properties of NNMT inhibitor, creating a useful in vivo probe for NNMT that can also be elaborated toward a therapeutic targeting the cancer microenvironment.
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Matthew Shair
Matthew Shair is a Professor in the Department of Chemistry and Chemical Biology at Harvard University, an associate of the Broad Institute and an affiliate of the Harvard Stem Cell Institute.
Join Us
Learn about joining our interdisciplinary team! Highly motivated graduate students and postdocs are always welcome.
Alumni
See our illuminous previous members and their current trajectories.