Potential processes for the co-formation of water and amide
The possible processes by which water and amide might co-form could be investigated by molecular dynamic simulations:
Taking combinations of amino acid (predominantly hydrophobic) to form 5mer peptides connected laterally by hydrogen bonds would be the first phase. 5 identical backbones would be the first “amide skin”. Oxygen and hydrogen (not a formed water molecule ) would then be brought up to the skin but not as formed water. Running the MD would find the positions needed for water to form abutting the skin.
One would therefore be determining in the MD simulations which order of amino acids were necessary for a skin, that aided the formation of water.
One would first use amino acid sequences from known proteolipid. It might be necessary to use a greater number than 5 for the initial skin.
If no process can be simulated one could start with the amide skin on/in HCN and then try and make a simulated topology where water can be the surface that replaces the HCN.
PDF link that considers Amide in HCN transfering to a Water phase and the connection of this system to information storage or memory.